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In this issue 15 papers · 5 free

01 Nature Ecology & Evolution Dispersal diversity buffers species vulnerability to local extinction Free
02 Proceedings of the National Academy of Sciences IGF2BP1 in 17q-gain cooperates with MYCN to regulate purine biosynthesis and immunotherapy efficacy in neuroblastoma Free
03 Science Advances Ocean circulation changes rather than global warming drove temperature trends across the Miocene Climatic Optimum Free
04 PNAS Nexus TIP-INN: A thermodynamics-informed machine learning framework for the mechanical behavior of rocks Free
05 Proceedings of the National Academy of Sciences Reproducibility of social science research using aggregate statistics with noise infused for differential privacy Free
06 Proceedings of the National Academy of Sciences How biological synapses self-assemble gradient learning Subscribers
07 eLife A membrane-disruptive action of VBIT-4 challenges its role as a widely used VDAC1 oligomerization inhibitor Subscribers
08 Nature Astronomy On the coronal origin of magnetic switchbacks in the solar wind Subscribers
09 Physical Review X Fluidic Hysterons and Memory in Flow Networks Subscribers
10 eLife Photo-downregulation of SIRT4 mitigates aging in mice by enhancing H3K9ac via fatty acid metabolism Subscribers
11 Nature Communications A cryptic binding pocket regulates the metal-dependent activity of Cas9 Subscribers
12 Nature Communications Consecutive waves of NODAL inhibition are required for epiblast patterning Subscribers
13 Nature Communications pH-responsive manganese carboxymethyl chitosan hydrogel releases pesticide to promote rice tillering and suppress root-parasitic weeds Subscribers
14 Science Advances Neanderthal woodworking at Abric Romaní: Insights into the role of wood in a Middle Palaeolithic domestic context Subscribers
15 Science Advances Human trilayer engineered blood vessel reveals influence of fibroblasts on disease progression in model of Hutchinson-Gilford progeria Subscribers

The papers Read free

Nature Ecology & Evolution·9 October 2026

Davide Bernardi, Giorgio Nicoletti et al.

Spreading offspring in more varied ways helps protect a species from dying out locally.

A new tool can predict which plants or animals in a community are at risk of dying out locally, using only data about where they live. It looks at how common a species is, how much its members vary in how they spread their offspring, and how it competes with its neighbors. Species with more varied spreading habits are safer from being pushed out, even if they are just as common as a less varied species. The tool was tested using real data from tropical and temperate forests.

What it could change A new way to measure a species' risk of dying out using only location data.

Tested using real tropical and temperate forest data, not yet other ecosystems.

Forest data only, so other ecosystems remain untested.

Integrity screen: passed (3 checks) Checked 30 October 2026. Davide Bernardi, Giorgio Nicoletti et al., Dispersal diversity buffers species vulnerability to local extinction Read the source

Proceedings of the National Academy of Sciences·9 October 2026

Jiaxu Liu, Yingzhe Fang et al.

In lab models, blocking one repair protein made aggressive neuroblastoma tumors respond better to immune therapy.

In lab models of a childhood cancer called neuroblastoma, two genetic changes often appear together and make the disease worse. A protein called IGF2BP1 teams up with a cancer driving gene to fuel a building block factory that makes DNA raw materials. Blocking a related repair protein made tumor cells more visible to the immune system. This made immune based drugs work better in lab models.

What it could change A drug combination made hidden tumor cells visible to the immune system in lab models.

Shows a lab demonstrated path to boost immune attack on aggressive neuroblastoma cells.

Lab and cell models only, no human trial data yet.

Integrity screen: passed (3 checks) Checked 12 October 2026. Jiaxu Liu, Yingzhe Fang et al., IGF2BP1 in 17q-gain cooperates with MYCN to regulate purine biosynthesis and immunotherapy efficacy in neuroblastoma Read the source

Science Advances·9 October 2026

Evi Wubben, Xiaoqing Liu et al.

Ancient ocean warming signal came from shifting currents, not a global carbon dioxide spike.

About 17 million years ago, deep sea records seemed to show a sudden burst of global warming. New ocean temperature data show this was not a real worldwide warming. Some places got warmer and others got cooler at the same time. Computer models suggest shifting ocean currents, not rising carbon dioxide, caused this uneven pattern.

The number 6 to 9 degrees Celsius

How much warmer than today the Early-to-Middle Miocene climate was overall, not just during the studied event.

Ancient climate data and models only, not a modern warming forecast.

Integrity screen: passed (3 checks) Checked 14 October 2026. Evi Wubben, Xiaoqing Liu et al., Ocean circulation changes rather than global warming drove temperature trends across the Miocene Climatic Optimum Read the source

PNAS Nexus·9 October 2026

Kangan Li, Tushar Mittal et al.

A new rock-behavior computer model trains much faster and makes far fewer errors than older tools.

A new computer model learns the hidden rules that control how rocks bend, crack, and flow under stress. It trains using real stress and strain data, and it never breaks the basic energy rules that real rocks must follow. Compared to older computer tools, it trains 10 to 30 times faster. It also makes errors up to 100 times smaller when tested on new conditions it has not seen before.

The number 10 to 30 times faster, up to 100 times fewer errors

How much faster and more accurate the new model is compared to older physics-based tools.

Lab data and computer models only, not tested underground yet.

Integrity screen: passed (3 checks) Checked 24 October 2026. Kangan Li, Tushar Mittal et al., TIP-INN: A thermodynamics-informed machine learning framework for the mechanical behavior of rocks Read the source

Proceedings of the National Academy of Sciences·9 October 2026

Ryan Steed, Eduardo Abraham Schnadower Mustri et al.

Privacy noise added to data kept 91% of original study findings intact.

Many companies and agencies add random statistical noise to data to protect people's privacy. Researchers tested 93 published social science studies to see if their main results still held up after this noise was added. About 91% of the findings still supported the original conclusions. Results based on weaker original effects were more likely to change or flip. The noise caused smaller problems than normal errors that already happen in this type of research.

The number 91%

The share of 93 study findings that still held up after privacy noise was added to the data.

93 studies only, using one type of statistical method.

Integrity screen: passed (3 checks) Checked 12 October 2026. Ryan Steed, Eduardo Abraham Schnadower Mustri et al., Reproducibility of social science research using aggregate statistics with noise infused for differential privacy Read the source

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Proceedings of the National Academy of Sciences·9 October 2026

Qianli Liao, Liu Ziyin et al.