Proceedings of the National Academy of Sciences · 7 October 2026 · From issue 48

Bone morphogenetic protein signaling as a key regulator of retinal fibrosis

In mice and rats, blocking a scar-forming signal shrank existing eye scar tissue.

Sonali Sharma, Gieth Alahdab et al.

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Also in issue 48 15 papers

A tribute honors immunologist Barry Bloom, who shifted immune research toward real disease germs.
Proceedings of the National Academy of Sciences
In mice, a protein plus exercise reduced depression-like behavior caused by a fatty diet.
PNAS Nexus
In mice, monkeys, and humans, one lung immune cell type grows over 10 times more common with healthy aging.
Nature Communications
Converted letter-by-letter AI models now match word-chunk models in performance.
Nature
Learning speeds up when people can simplify many goals into one simple rule.
Nature Communications
In lab-grown human immune cells, mpox virus causes inflammation and cell death that one drug combo blocked.
Proceedings of the National Academy of Sciences
Ocean carbon storage drops sharply when sea life disappears, but storm protection relies on just a few species.
Nature Ecology & Evolution
Hidden black holes stir up gas far outside their home galaxy's center, new X-ray data shows.
The Astrophysical Journal
A hybrid physics and learning model predicts how complex gels and pastes flow and stiffen.
PNAS Nexus
A laser locked to an atom's core built a working nuclear clock for the first time.
Nature
In zebrafish and human cells, one protein both calls immune cells to wounds and protects healing tissue.
Nature
In a theoretical model, acting agents must trade off predicting the future against saving energy.
Physical Review X
A finished water gel can be rewired from the inside, changing its strength and shape without breaking it apart.
Nature Communications
In a climate model, over 40% of world river basins will lose usable water by 2100.
Geophysical Research Letters

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