Proceedings of the National Academy of Sciences · 7 October 2026 · From issue 48

Infection of macrophages by mpox virus activates inflammasome and cell death, informing multitarget therapeutic strategies

In lab-grown human immune cells, mpox virus causes inflammation and cell death that one drug combo blocked.

Yining Wang, Xin Wang et al.

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Also in issue 48 15 papers

A tribute honors immunologist Barry Bloom, who shifted immune research toward real disease germs.
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In mice, a protein plus exercise reduced depression-like behavior caused by a fatty diet.
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In mice, monkeys, and humans, one lung immune cell type grows over 10 times more common with healthy aging.
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Converted letter-by-letter AI models now match word-chunk models in performance.
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Learning speeds up when people can simplify many goals into one simple rule.
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In mice and rats, blocking a scar-forming signal shrank existing eye scar tissue.
Proceedings of the National Academy of Sciences
Ocean carbon storage drops sharply when sea life disappears, but storm protection relies on just a few species.
Nature Ecology & Evolution
Hidden black holes stir up gas far outside their home galaxy's center, new X-ray data shows.
The Astrophysical Journal
A hybrid physics and learning model predicts how complex gels and pastes flow and stiffen.
PNAS Nexus
A laser locked to an atom's core built a working nuclear clock for the first time.
Nature
In zebrafish and human cells, one protein both calls immune cells to wounds and protects healing tissue.
Nature
In a theoretical model, acting agents must trade off predicting the future against saving energy.
Physical Review X
A finished water gel can be rewired from the inside, changing its strength and shape without breaking it apart.
Nature Communications
In a climate model, over 40% of world river basins will lose usable water by 2100.
Geophysical Research Letters

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