Nature Communications · 13 October 2026 · From issue 51
CD200+ fibroblasts prime the immunoregulatory function of granulocytic myeloid-derived suppressor cells in inflammatory arthritis
In mice, joint lining cells train immune cells to calm inflammation, and blocking this made arthritis worse.
Mario R. Angeli, Christian Schütz et al.
Certain immune cells can calm down joint inflammation, but only inside the joint itself, not in the blood. Cells in the joint lining send signals that turn young immune cells into these calming cells. In mice with arthritis, blocking that signal stopped the calming cells from forming. This made the disease worse.
Shows a joint tissue signal that helps control inflammation in mice with arthritis.
Mouse and cell studies only, no human trial yet.
Integrity screen: passed (3 checks) Checked 14 October 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (Nature Communications). Read the source
This screen checks process signals. It does not tell you the findings are true.