Nature Communications · 27 October 2026 · From issue 58
NK cells engineered with a chimeric antigen receptor delay HIV rebound and reshape HIV reservoir composition
In mice, engineered immune cells delayed HIV's return and shrank the variety of virus that came back.
Yuan Shi, Izra Abbaali et al.
Engineered immune cells slowed the return of HIV after treatment stopped in mice. Scientists built natural killer cells with an added sensor that spots a hidden marker on HIV-infected cells. The cells hunted and killed infected cells in lab dishes. In mice, they also cut the number of virus types that came back and pushed the leftover virus into harder-to-wake hiding spots.
Shows a lab and mouse result, not a proven treatment for people.
Humanized mice only, no human safety or efficacy data yet.
Integrity screen: passed (3 checks) Checked 28 October 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (Nature Communications). Read the source
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