Nature · 28 October 2026 · From issue 59
Pharmacological inhibition of METTL1 as a therapy against solid and blood cancers
In mice and lab cells, a new drug shrank tumors by blocking a protein-building enzyme.
Eliza Yankova, Alexandra Sapetschnig et al.
A new drug called STM9005 blocks an enzyme cancer cells need to build proteins. The enzyme normally tags tiny molecules that cells use as instructions for making proteins. In lab-grown cancer cells, the drug stopped growth. In mice with cancer, it shrank tumors and helped them live longer.
Shown only in lab cells and mice, across cancers like leukemia, melanoma, and lung cancer.
Mice and lab cells only, no human trials yet.
Integrity screen: passed (3 checks) Checked 30 October 2026. Retraction record: none. DOI resolves at doi.org. Metadata record found (Nature). Read the source
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